Safe Prozac

A herb’s impact on brain compared to Big Pharma’s notorious drug

Selective serotonin reuptake inhibitors (SSRIs), such as Prozac, Zoloft, and Celexa, affect serotonin levels in the brain. Although SSRIs are the first choice of treatment for mild depression or anxiety, a study finds that the herbal extract St. John’s wort works equally well. The researchers, writing in the journal Affective Disorders, looked at 27 clinical trials with a total of 3,808 patients, comparing the use of St John's wort and SSRIs. In patients with depression, “St John's wort demonstrated comparable response … and remission rate, and significantly lower discontinuation/dropout rate compared to standard SSRIs.”

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