Age Reverser NMN

Suppressed age-related weight gain, enhanced metabolism, improved insulin sensitivity and vision in mice

NMN

NMN

If you haven’t tried NMN supplements yet you may want to. NMN supplements are being touted to restore the body’s supplies of an enzyme called nicotinamide adenine dinucleotide (NAD+), a factor in metabolism, aging, cell death, DNA repair, and gene expression.

The reason for the excitement is that experimental studies suggest its human potential. “Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair,” Christopher Shade, PhD, writes in the journal Integrative Medicine.

“Nicotinamide adenine dinucleotide (NAD) pharmacology is a promising class of treatments for age-related conditions that are likely to have a favorable side effect profile for human use,” notes an article in Pharmaceuticals.

“Taken orally, NMN is rapidly absorbed and converted to NAD+,” the scientists write. “In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more.” “In fact, the slow, ineluctable process of aging has been described as a ‘cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues,’” adds Dr. Shade. “By middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).”

JAPANESE STUDY

A study in Cell Metabolism produced exciting results. The scientists conducted a 12-month-long study of NMN administration to mice during their normal aging.

Orally administered NMN was quickly utilized to synthesize NAD+ in tissues. “Remarkably, NMN effectively mitigates age-associated physiological decline in mice. Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies. Consistent with these phenotypes, NMN prevented age-associated gene expression changes in key metabolic organs and enhanced mitochondrial oxidative metabolism and mitonuclear protein imbalance in skeletal muscle. These effects of NMN highlight the preventive and therapeutic potential of NAD+ intermediates as effective anti-aging interventions in humans.”

References

Christopher Shade The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule Integr Med (Encinitas) 2020 Feb;19(1):12-14 PMCID: PMC7238909

Dina Radenkovic, Reason, and Eric Verdin Clinical Evidence for Targeting NAD Therapeutically Pharmaceuticals (Basel). 2020 Sep; 13(9): 247. Published online 2020 Sep 15. doi: 10.3390/ph13090247 PMCID: PMC7558103 PMID: 32942582

Kathryn F Mills, Shohei Yoshida, Liana R Stein, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice Cell Metab 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27.
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