Korean Ginseng Changes Biochemistry of Fatigue

Restoring blood scores

Woman running in nature

Woman running in nature

Scientists studying athletic performance observe that strength-endurance training results in an elevation of creatine kinase (CK) and blood urea nitrogen (BUN), and a reduction in blood hemoglobin, which are biochemical signs of fatigue.

In this study, administration of Korean ginseng led to a “marked reduction” in CK and BUN and restored biochemical scores close to normal, suggesting that the change in metabolic profiling could reflect the anti-fatigue effect of Korean ginseng.

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In a second study, it was shown that highest doses work best. Sedentary individuals were randomly assigned into one of three groups: low-dose ginsenoside supplementation (100 milligrams [mg]/d), high-dose ginsenoside supplementation (500 mg/d), or a placebo group.

All participants underwent a supervised 12-week aerobic and resistance exercise training course. To assess the effects of supplementation on physical performance, maximal oxygen consumption (VO2max), anaerobic threshold (AT), lactic acid, and muscle strength of the dominant knee were measured at baseline, every visit, and after the training program.

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Both ginsenoside groups showed significant increases in VO2max and muscular strength during exercise training. However, for overall performance, “high-dose ginsenoside supplementation augmented the improvement of aerobic capacity by exercise training.”

References i Yan B, Liu Y, Shi A, Wang Z, Aa J, Huang X, Liu Y. Investigation of the Antifatigue Effects of Korean Ginseng on Professional Athletes by Gas Chromatography-Time-of-Flight-Mass Spectrometry-Based Metabolomics.J AOAC Int. 2018 May 1;101(3):701-707. doi: 10.5740/jaoacint.17-0220. Epub 2017 Sep 19.

ii Lee ES, Yang YJ, Lee JH, Yoon YS. Effect of high-dose ginsenoside complex (UG0712) supplementation on physical performance of healthy adults during a 12-week supervised exercise program: A randomized placebo-controlled clinical trial. J Ginseng Res. 2018 Apr;42(2):192-198. doi: 10.1016/j.jgr.2017.03.001. Epub 2017 Apr 5.
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