Age Reversal Cocktail

3 drugs show resetting of the body’s genetic clock

Happy woman drinking tropical drink

Happy woman drinking tropical drink

Aging is controlled by an epigenetic clock that keeps time by marking changes, called methylations, to the body’s epigenome. These modifications are correlated with biological age and are “tagged” on our body’s DNA within the chromosome.

Geneticist Steven Horvath of the University of California, Los Angeles, is thought to have created an extremely accurate epigenetic clock. Gregory Fahy is the chief scientific officer and co-founder of Intervene Immune in Los Angeles. He has been studying thymus rejuvenati0n since 1986, a time when growth hormone (GH) was shown experimentally to rejuvenate the immune system. The thymus gland is situated between the lungs and the breastbone and regulates the immune function but begins its shrinking, read aging, at puberty.

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When Dr. Fahy turned 46, he combined growth hormone and DHEA to regenerate his thymus gland and saw modest improvements.

Dr. Fahy then began the Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial in 2015.

In this small clinical trial, published in Aging Cell, GH, dehydroepiandrosterone (DHEA), and metformin were given to nine healthy volunteers, aged 51-65, age at Stanford Medical Center in Palo Alto, California.

Use of the drug cocktail led them to reverse 2.5 years off their biological age, measured by analyzing methylations markers on their genomes. The participants’ immune systems also showed signs of rejuvenation, indicating possible thymus rejuvenation.

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“I’d expected to see slowing down of the clock, but not a reversal,” says Dr. Horvath who examined their epigenetic markers. “That felt kind of futuristic.”

Dr. Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests. “This told me that the biological effect of the treatment was robust,” he told the media. The effects persisted even six months after their last treatment, he adds. “Because we could follow the changes within each individual, and because the effect was so very strong in each of them, I am optimistic.”

Metformin is being closely studied now for age-reversal effects and protection against cancer and heart disease. The three drugs together could be acting individually or in concert. The researchers aren’t sure and plan a larger clinical trial.

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