Anti-Alzheimer’s Vitamin

Folic acid correlates with higher cognitive scores

Joyful woman

Joyful woman

Writing in the American Journal of Alzheimer’s Disease & Other Dementias, researchers in Istanbul’s, Turkey, Bezmialem Vakif University report the results of a small study that looked at levels of cholesterol and B vitamins in the blood of some 80 participants. They found that “High levels of HDL [high-density lipoprotein], vitamin D, and folic acid correlate” with highest cognitive scores. High levels of total cholesterol, HbA1c (a marker for diabetes), and low-density lipoprotein show a “negative effect on cognition scores.”

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In a second study, folic acid improved the condition of early-onset Alzheimer’s patients when given as a supplement. Low serum folate levels can alter inflammatory reactions, the scientists said. “Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation's effect on inflammation and cognitive function in patients with AD over the course of 6 months.”

121 patients included those newly diagnosed with AD (age > 60 years) with mild to severe symptoms, being treated with donepezil, they were randomly assigned into two groups with (intervention group) or without (control group) supplemental treatment with folic acid (1.25 mg/d) for 6 months.

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The Mini-Mental State Examination was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment. The higher the serum folate, the lower were all the positive markers for Alzheimer’s disease including less amyloid beta, interleukin-6, tumor necrosis factor α, and plasma homocysteine.

“Folic acid is beneficial in patients with AD. Inflammation may play an important role in the interaction between folic acid and AD,” concludes the research.

ReferenceGokce M, Bektay MY, Selvitop R, Toprak A, Yildiz GB.Investigation of the Effects of Biochemical Parameters on Alzheimer's Disease.Am J Alzheimers Dis Other Demen. 2019 Jul 16:1533317519862108. doi: 10.1177/1533317519862108. [Epub ahead of print] ii Hui Chen, Shuai Liu, Lu Ji, 3 Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, and Guowei Huang Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial Mediators Inflamm. 2016; 2016: 5912146. Published online 2016 Jun 2. doi: 10.1155/2016/5912146 PMCID: PMC4909909 PMID: 27340344
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