Ease Autism

Irritability, lethargy, hyperactivity can be managed

Kid running

Kid running

A new research shows that incidence of aberrant behavior in children with autism spectrum disorders (ASD) may be reduced by regulating the imbalance with a combination of bovine colostrum with probiotics.

Over half of children with autism spectrum disorders have gastrointestinal (GI) disturbances including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial imbalances.

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A small but well-controlled pilot study from researchers at the University of California, Davis, reported in PLoS One, assessed the tolerability of BC when combined with the beneficial bacterial species Bifidobacterium infanti for its benefits in children with ASD and GI.

This study looked at eight children, ages 2-11, for 12 weeks that included 5 weeks of BC and probiotics, followed by a two-week washout period, and 5 weeks of the probiotic only.

The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects.

“Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors,” the study team noted.

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In particular, “We found significant reduction of certain aberrant behaviors, including irritability, lethargy, stereotypy [self-stimulatory behaviors], and hyperactivity…”

The scientists said improvement was explained by a reduction in inflammatory messenger chemicals such as interleukin-13 (IL-13), linked with allergies and GI disturbances, and tumor necrosis factor-α (TNF-α), a highly inflammatory cytokine. Both are frequently found at high levels in the autism-affected population.

Reference Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, Yang HT, Tancredi DJ, German JB, Slupsky CM, Ashwood P, Mills DA, Smilowitz JT, Angkustsiri K. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 2019 Jan 9;14(1):e0210064. doi: 10.1371/journal.pone.0210064. eCollection 2019.
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